Somatic mutation& A mutation occurring in a somatic cell rather than in the germline. 发生在体细胞而非种系中的可遗传的变异。
Here, we investigate the possibility of whether a tumor cell nucleus, in which transformation is caused by somatic mutation, can be epigenetically reprogrammed into normal tissues. 在这里,我们调查的,是由体细胞突变引起的肿瘤细胞的细胞核,能被后生重编程进入正常组织的可能性。
Impact of Immunoglobulin Gene Somatic High Mutation on Prognosis of the Chronic Lymphocytic Leukemia& Review 免疫球蛋白基因体细胞高突变对慢性淋巴细胞白血病预后的影响
Somatic Mutation of PTEN in Prostate Cancer 前列腺癌中PTEN基因突变
Objective To prepare anti GPA McAb for establishing GPA somatic mutation assay. 目的制备抗GPA单克隆抗体以建立“GPA体细胞突变分析法”。
The present paper reports the study on the genetic injuries of somatic and germ cells induced by internal radionuclide exposure. Emphasis is placed on the molecular basis of radio-genetic effect and the relations of the molecular basis of DNA injury to gene mutation and chromosome aberration. 文中探讨了受放射性核素内照射诱发体细胞和生殖细胞的遗传损伤效应,以及内照射核素诱发放射遗传效应的分子基础DNA损伤与基因突变和染色体畸变的关系。
Objective: The relative studies of somatic mutation and reproduction abnormality clinical effect. 目的对单个细胞染色体畸变在临床引起生殖异常效应的相关性研究;
Comparison of mitochondrial DNA somatic mutation in patients with breast cancer between Chinese Han people and American Caucasians 中国汉族人与美国高加索人乳腺癌患者线粒体基因细胞突变的比较
Comparison of somatic mutation frequencies at HGPRT locus induced by radiation and chemical pollutant from energy system 能源循环释放的辐射和化学污染物致体细胞HGPRT基因位点突变的比较研究
Comparative Study on Multinucleated Cell Assay and Brdurd Labeling in Detecting the Somatic HPRT Gene Mutation Induced by Radiation 多核细胞法和Brdurd法检测辐射诱发体细胞HPRT基因突变的比较研究
This article reports the study of cleavage and differentiation and monoclone culture of the somatic cells which were enzymic-degraded from thallus of Porphyra haitanensis after inducing mutation by()~ ( 60) Co-γ ray irradiation. 本文报道了坛紫菜叶状体经60Coγ射线辐照后,用酶解方法获得离体细胞,观察了体细胞的分裂分化及进行单克隆培养叶状体。
Study on the relationship between dose-rates and somatic cell mutation at HPRT locus induced by late fission products 晚期混合裂变产物内照射诱发体细胞HPRT基因位点突变率与剂量率关系的研究
Development of a human somatic mutation detection method& GPA assay 人体细胞突变检测GPA分析方法的建立
Genomic instability involving structure alterations and epigenetic effect stems from germline and somatic mutation and related to genetic susceptibility of cancer. 基因组不稳定性与癌的遗传易感性相关,涉及基因组结构改变和表遗传效应,来源于胚系突变和体细胞突变。
The genomic instability of cancer stems from germ-line mutation and somatic mutation. 癌基因组不稳定性来源于胚系突变和体细胞突变。
Such embryogenic cell suspension culture will provide ideal donors for induced somatic mutation, somatic hybridization, and genetic transformation. 这样的胚性细胞悬浮培养系将成为细胞水平突变、体细胞杂交和遗传转化的理想供体。
Most of the chlorophyll deletion occurred in M1 were belonged to somatic mutation or caused by radiation injury so that they usually were not inheritable. 在M1所产生的叶绿素缺失中,大多数属于体细胞突变,或是由于辐射损伤所致,一般是不能遗传的;
Feasibility study of radiation dose estimation using somatic HPRT gene mutation 体细胞HPRT基因突变检测用于辐射剂量估算的可行性研究
Results: Observation 4 cases with somatic mutation have clinical effect. 结果发现4例体细胞突变均有临床效应;
Objective: To develop the glycophorin A ( GPA) somatic cell mutation assay. 目的:为了建立血型糖蛋白A(GlycophorinA,GPA)突变分析技术。
According to the result, we may conclude that BrdU labeling method is a quick, simple and relatively sensitive method for detecting the HPRT gene mutations of somatic cells induced by external radiation exposure and HPRT gene mutation may be used as a radiobiological dosimeter. 研究证明了BrdU法是一种快速、简便、较敏感的检测外照射诱发HPRT基因突变的方法,HPRT基因辐射突变可作为生物剂量计。
Relationship between somatic hyper mutation and the pathogenesis of B cell lymphoma 体细胞超突变与B细胞淋巴瘤
The body always is affected by all kinds of carcinogenic factors that lead to tumor development. Tumor is a neoplasm which forms under some DNA impairment in definite chromosome that causes somatic cell mutation and clonally abnormality hyperplasia. 肿瘤通常是指机体在各种致癌因素作用下,由于某些特定染色体上的DNA损伤引起体细胞发生突变而导致其克隆性异常增生形成的新生物。
Previous studies in our laboratory have ruled out the possibility of somatic cell clonal variation. The external pressure in the transgenic processes may increase the mutation rate of plants. So the emergence of the mutant may be related to the process of genetic transformation. 本实验室前期的研究已经排除了突变体为无性系变异的可能,因此,该突变体的出现很可能与遗传转化过程有关,植物转基因过程中形成的外部压力有可能增加了受体的突变率。
But neither methylation or somatic mutation is main cause of MSI-H CRC. 基因甲基化是MSI-H胃癌的主要原因。
In recent years, plant tissue culture and suspension cell culture have been the basic technologies on breeding new varieties by the approaches of somatic cells mutation, cell fusion and genetic transformation. 近年来,植物组织培养和细胞培养已成为细胞诱变、细胞融合、遗传转化途径培育新品种的基础技术。
Somatic mutation, a main biological phenomenon of citrus and other fruits, is often used for breeding as a major variation source. 体细胞突变是柑橘等果树比较常见的生物学现象,也是品种选育,即芽变选种的主要变异来源。